The most important changes:

Powerful artifacts have made it into the hands of dungeon denizens! Starting at level 3, watch out for powerful enemies you might be better off avoiding, though the items they carry might be worth the risk.
Food will now heal you slightly, if consumed.
Lots of new keyboard commands: 'v' to cast a spell, 1 to 0 to directly use the hotbar and single items are now picked up without opening the inventory. And there's even more though!
Resting until healing, and resting until power recharge.
Better controller support.
Many UI changes, like e.g. a permanently open game log, which you can toggle in the options.
Some balancing changes, e.g. tuning down some weapon skills, which were scaling too much damage.
And much more! See the full release notes below!

Have fun - we are looking forward to your continuing feedback!

Please find below the detailed change notes:

Enhancements:

The caverns just got a lot more deadly. Starting at dungeon level 3, you may encounter powerful mini boss monsters carrying unique artifacts with them. Don't forget that avoiding powerful enemies is a valid response! Defeating these creatures will tax your mastery of your skills.
Food no longer is useless. While Hunger and the full Food system (including the beloved feasting on enemy corpses to gain new abilities) will not make it into the game before March, you no longer have to rely on harvesting food items for them to benefit you. Consuming food will now provide a small health boost.

Now, you can cast spells directly via 'v' verbalising them without going through the action menu.
Healing until rested (or interupted) is now available by holding 'Shift' and either <Space> or <5> on the Numpad. Like auto-exploring, you can stop this at any time by pressing a key, clicking the mouse or the gamepad.
If you hold 'Shift' and 'v', your character will rest until interrupted, or when at full Power for more spellcasting.
In addition to using <Space> or <5> on the numpad to wait a turn, you can now also use '.' as used by other rogue-likes.
If you press ',' to pick up items and a single item is lying on the ground it is directly picked up without having to open the inventory.
The entries in the toolbar can now be activated with the hotkeys '1' to '0’.

The repeat delay and repeat rate can now be configured separately from the keyboard settings. By our experience, the new defaults were slightly too fast for controllers.
You can now pick up items with the <Y> button.
The dead zones for some gamepad axis are now increased which should prevent getting erroneous input from other input devices that use the same axis (e.g. HOTAS setups).

Item weight no longer is shown in the item tooltips, because our current inventory system is slot-based instead of weight-based right now.

The game log is shown all the time now. You can change this in the settings or simply change the transparency.
Certain panels should no longer look weird on very wide displays.
Now, the game is allowed to render in the background (on Windows), making it a true “borderless window”. E.g. if you press Alt+Tab, the start menu will open now on top of the game window, instead of minimizing it.
The saved games list displays now, which saved games are compatible with the current game version and which ones are not.
The default speed for animations has been reduced back again to saner levels. You can still change it to whatever speed you prefer. You (speed-)monster.

Weapon skills have been toned down, as they scaled the possible damage up way too far.
Dworjalf is no longer the one-man-army-dwarf he used to be. He will deal slightly less damage with his axes, and will take slightly more damage now.
Tisseth is now skilled in using the quarterstaff she starts with. She lost all interest in archery.

Now, we create a backup of a saved game before it will be overwritten. There is no automatic recovery, yet.
You will find more armor and weapons from different materials, especially as you venture deeper into the caves.
Slain monsters will take expensive items with them upon their deaths much less often.
Size no longer matters. You can now wear any armor and wield any weapon you find.

Fixed the spell buff skills for increased range and damage. Most did not quite work out as we expected.
Items on the ground are now shown correctly after loading a game.
The “low hitpoints” warning border is restored correctly now, after loading a game.
Encumbrance always is now correctly updated, when you pick up or drop items in the inventory screen.
Tooltips in the inventory screen are now always correctly updated, when equipment changes.
Items lying at your position are now shown directly after loading a game.
A lot of fixes entering new maps.
And lots of minor bug-fixing and fine-tuning.

Thomas Biskup, the man behind ADOM, has recently adressed your feedback and gave some insights into the current state of the Early Access.
Feel free having a look, if you have not already:
https://store.steampowered.com/news/app/1266820/view/3023575557497021344